Paraganglioma like adenoma of thyroid: rare neoplasm of thyroid – case report and review of literature

Main Article Content

Surabhi Garg
Loreno Enny
Tarun Patel

Abstract

Paraganglioma like adenoma of thyroid (PLAT) also known as Hyalinizing trabecular adenoma is a rare neoplasm of the thyroid, arising mostly in middle aged women. The histological resemblance to paraganglioma, papillary and medullary carcinoma of thyroid may often lead to confusion. Immunohistochemical markers often help in establishing diagnosis. The biology and clinical course is of such tumours is often considered to be benign, however further studies are needed to establish the same. We herein present a case of a 30 year old lady who presented with a long standing goitre, and was diagnosed to be a case of PLAT on final histopathology.

Article Details

How to Cite
Garg, S., Enny, L., & Patel, T. . (2023). Paraganglioma like adenoma of thyroid: rare neoplasm of thyroid – case report and review of literature . Journal of Surgery Archives, 2(01), 1–3. Retrieved from https://jsurgarchives.com/index.php/ijsa/article/view/46
Section
Case Report

References

Bronner MP, LiVolsi VA, Jennings TA. PLAT: paragangliomalike adenomas of the thyroid. Surg Pathol 1988; 1: 383-9. 2.

Smith NR, Bullock MJ, Hart RD, et al. Hyalinizing trabecular tumour: review and new insights into the molecular biology. Otolaryngol Head Neck Surg. 2012;41(1):30-34.

Carney JA, Ryan J, Goellner JR. Hyalinizing trabecular adenoma of the thyroid gland. Am J Surg Pathol 1987; 11: 583-91.

Casey MB, Sebo TJ, Carney JA. Hyalinizing trabecular adenoma of the thyroid gland: cytologic features in 29 cases. Am J Surg Pathol. 2004;28:859-867.

Cheung CC, Boerner SL, MacMillan CM, et al. Hyalinizing trabecular tumor of the thyroid: a variant of papillary carcinoma proved by molecular genetics. Am J Surg Pathol. 2000;24:1622-1626.

Ertan Y, Makay Ö, Veral A, Tamsel S, İçöz G, Tunçyürek M. Hyalinizing trabecular tumor of the thyroid. Turk Patoloji Derg. 2009;25:44–46. doi: 10.5146/tjpath.2009.00971.

DeLellis RA, Lloyd RV, Heitz PU, Eng C, editors. Pathology and Genetics of Tumours of Endocrine Organs. Lyon: IARC Pres; 2004. World Health Organization Classification of Tumours.

Lester DR, Thompson MD. Hyalinizing trabecular adenoma of the thyroid gland. Ear Nose Throat J. 2011;90:416–417

Gowrishankar S, Pai SA, Carney JA. Hyalinizing trabecular carcinoma of the thyroid gland. Histopathology. 2008;52:529–531. doi: 10.1111/j.1365-2559.2008.02945.x.

Yu BH, Sheng WQ, Wang J. Primary paraganglioma of thyroid gland: a clinicopathologic and immunohistochemical analysis of three cases with a review of the literature. Head Neck Pathol. 2013 Dec;7(4):373-80. doi: 10.1007/s12105-013-0467-7

Ergün S, Akıncı O, Öztürk T, Karataş A. Hyalinizing trabecular tumor of the thyroid gland. Turk J Surg. 2018 Jan 3;34(2):149-151. doi: 10.5152/UCD.2017.3221

Hirokawa M, Shimizu M, Manabe T, Kuroda M, Mizoguchi Y (1995) Hyalinizing trabecular adenoma of the thyroid: its unusual cytoplasmic immunopositivity for MIB1. Pathol Int 45: 399–401.

Lee S, Han BK, Ko EY, Oh YL, Choe JH, et al. (2011) The ultrasonography features of hyalinizing trabecular tumor of the thyroid are more consistent with its benign behavior than cytology or frozen section readings. Thyroid 21: 253–259.

Ito Y, Hirokawa M, Kousaka K, Ito M, Kihara M, Miya A, Miyauchi A. Diagnosis and management of hyalinizing trabecular tumor of the thyroid: a single-institution experience. Endocr J. 2021 Dec 28;68(12):1403-1409. doi: 10.1507/endocrj.EJ21-0143. Epub 2021 Jul 6. PMID: 34234050.

Nikiforova MN, Nikitski AV, Panebianco F, Kaya C, Yip L, et al. (2019) GLIS rearrangement is a genomic hall‐ mark of hyalinizing trabecular tumor of the thyroid gland. Thyroid 29: 161–173.